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Spatial Manipulation of Particles and Cells at Micro- and Nanoscale via Magnetic Forces. Panina, Anastasiya Gurevich, Anna Beklemisheva, Alexander Omelyanchik, Kateryna Levada, Valeria Rodionova. Analysis of Magneto-Hyperthermia Duration in Nano-sized Drug Delivery System to Solid Tumors Using Intravascular-Triggered Thermosensitive-Liposome.

Mohammad Souri, Farshad Moradi Kashkooli, M.

An Updated Review on EPR-Based Solid Tumor Targeting Nanocarriers for Cancer Treatment. Cho, Asal Ansariesfahani, Rahil Tarharoudi, Hedyeh Malekisarvar, Soyar Sari, Samir Haj Bloukh, Zehra Edis, Mohamadreza Amin, Jason P. Recent Advances in Drug Delivery Nanocarriers for Targeting Hepatocellular Carcinoma.

Shanshan Wang, Qianzhou Lv, Xiaoyu Li.

Magnetic Nanoparticles: Current Advances in Nanomedicine, Drug Delivery and MRI. Enhancing non-invasive brain stimulation with non-invasively delivered nanoparticles for improving stroke recovery. Tale of Two Magnets: An Advanced Magnetic Targeting System.

Zijian Zhou, Zheyu Shen, Xiaoyuan Chen.

ACS Applied Materials & Interfaces 2021, 13 Magnetically Guided Nanoworms for Precise Delivery to Enhance In Situ Production of Nitric Oxide to Combat Focal Bacterial Infection In Vivo. Bitao Lu, Enling Hu, Ruiqi Xie, Kun Yu, Fei Lu, Rong Bao, Chenhui Wang, Guangqian Lan, Fangyin Dai.Magnetic Nanostructures: Rational Design and Fabrication Strategies toward Diverse Applications.

Shuren Wang, Junjie Xu, Wei Li, Shengnan Sun, Song Gao, Yanglong Hou.

ACS Applied Materials & Interfaces 2022, 14 Targeting Magnetic Nanoparticles in Physiologically Mimicking Tissue Microenvironment.

Soumya Bhattacharya, Kiran Raj M, Jyotsana Priyadarshani, Ranjan Ganguly, Suman Chakraborty.

This article is cited by 35 publications. Using this method, we demonstrate a 5-fold increase in the penetration and a 3-fold increase in the accumulation of magnetic nanoparticles within solid tumors compared to EPR.

To overcome this problem, we have developed a system comprising two oppositely polarized magnets that enables the penetration of magnetic nanocarriers into more deeply seeded tumors. However, because magnetic fields fall off rapidly with distance from the magnet, these methods have been limited to use in superficial tumors. Previous strategies have shown that magnetophoresis enhances accumulation and penetration of nanoparticles into solid tumors. When exploiting the enhanced permeability and retention (EPR) effect for passive targeting of nanocarriers, the increased interstitial fluid pressure and dense extracellular matrix in tumors limits the distribution of the nanocarriers to perivascular regions. Drug delivery to solid tumors is hindered by hydrostatic and physical barriers that limit the penetration of nanocarriers into tumor tissue.